Peptic ulcer, inflammatory bowel or chronic liver disease. Jaundice, hepatic cirrhosis. Regularly check liver enzyme levels (ALT, AST, γ-GT, ALP, total bilirubin); perform liver function test. Severe pancreatic disease; choledocholithiasis; variceal bleeding, hepatic encephalopathy, ascites & those in need of urgent liver transplantation. Avoid in pregnancy. Women of childbearing potential. Elderly.
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